This study is open to adult patients with solid tumors who have a KRAS G12V mutation. This mutation is often found in non-small cell lung cancer (NSCLC), colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC) and other cancers. The study is for patients whose cancer has spread through the body and for whom previous treatments were not successful or treatment does not exist. Patients must also be positive for HLA-A*11:01. The purpose of this study is to find the best dose of AFNT-211 that is safe and can shrink tumors in patients. AFNT-211 is an investigational therapy and this is the first time that AFNT-211 is being administered to patients. AFNT-211 is an autologous T cell product which means that it is made from a patient's own T cells. These cells are engineered and grown to recognize the KRAS G12V protein on the cell surface of cancer cells. AFNT-211 is infused into patients after a short course of lymphodepleting chemotherapy. Patients will frequently visit the study site. The doctors there will regularly check the size of the cancer and the patient's health. They will also take note of any unwanted effects. Patients may continue in this study for as long as they benefit from the treatment.
Sponsor
Affini-T Therapeutics, Inc.
Status of enrollment
Accepting new patients
Ages Eligible for Study
Adults aged 18 and older
Genders Eligible for Study
Female and Male
Disease indication
Pancreatic Ductal Adenocarcinoma, Lung Cancer, Non-Small Cell Lung Cancer, Colorectal Cancer, Solid Tumor, KRAS G12V
Principal Investigator
Bridget Keenan, MD, PhD
Contact
Additional study eligibility details can be found at UCSF Clinical Trials.